Due to the fact that in decompensated HF these elevated renal venous pressures are perpetuated, there is an activation of the renin-angiotensin-aldosterone system (RAAS) and neurohormonal system, which causes vasoconstriction of the afferent arteriole to ensure renal blood flow that ultimately produces a reduction in the GFR. Editor/authors are masked to the peer review process and editorial decision-making of their own work and are not able to access this work in the online manuscript submission system. Feasibility of remote technical support for electrophysiological ablation procedures during the current COVID-19 pandemic Its only stable isotope is 23 Na. A dissociation between structural and functional changes was first recognized at autopsy of World War II soldiers with acute kidney failure and death (vasoconstriction and volume depletion insults. Aldosterone is a hormone that increases the absorption of water from the distal convoluted tubule and collecting duct of the kidney's nephrons. It converts the hormone angiotensin I to the active vasoconstrictor angiotensin II.Therefore, ACE indirectly increases blood pressure by causing blood vessels to constrict. These three act to elevate Angiotensin receptor blockers (also called ARBs or angiotensin II inhibitors) are medicines that dilate (widen) blood vessels, and are used in the treatment of conditions such as high blood pressure (hypertension), heart failure, or kidney disease in people with diabetes.. The impetus of the membership remains research-based academic surgery, and to promote the shared vision of research and academic pursuits through the exchange of ideas between senior surgical residents, junior faculty and established academic surgical Valsartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, olmesartan, and irbesartan.ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its Natural and OTC vasodilators are available. It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys. Half-Life: 5-9 hr. Location within the body. Essential hypertension (also called primary hypertension, or idiopathic hypertension) is the form of hypertension that by definition has no identifiable secondary cause. Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Valsartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, olmesartan, and irbesartan.ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its KI is peer-reviewed and publishes original research in both While most systems of the body show some degree of autoregulation, it is most clearly observed in the kidney, the heart, and the brain. Peak Plasma Time: 3-4 hr. About the Societies. This conversion is a crucial step in blood pressure control as angiotensin II causes vasoconstriction and increases blood pressure and constriction of efferent arterioles in the kidneys. Kidney function. Due to the fact that in decompensated HF these elevated renal venous pressures are perpetuated, there is an activation of the renin-angiotensin-aldosterone system (RAAS) and neurohormonal system, which causes vasoconstriction of the afferent arteriole to ensure renal blood flow that ultimately produces a reduction in the GFR. Valsartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, olmesartan, and irbesartan.ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its Water metabolism by the kidney can be classified into regulated and obligate. Under the editorial leadership of Dr. Pierre Ronco (Paris, France), KI is one of the most cited journals in nephrology and widely regarded as the world's premier journal on the development and consequences of kidney disease. Kidney International (KI) is the official journal of the International Society of Nephrology. Numerous drugs can cause ATI/ATN. J Cardiovasc Pharmacol 1984; 6 Suppl 4:S575. ARBs work by blocking the action of a natural chemical called angiotensin II. Essential hypertension (also called primary hypertension, or idiopathic hypertension) is the form of hypertension that by definition has no identifiable secondary cause. It is the most common type affecting 85% of those with high blood pressure. The angiotensin receptor is activated by the vasoconstricting peptide angiotensin II. ARBs work by blocking the action of a natural chemical called angiotensin II. 45 Issue 1 Supplement S5S67. Neurotherapeutics is the journal of the American Society for Experimental Neurotherapeutics (ASENT). Your doctor may do blood tests to check for this. KI is peer-reviewed and publishes original research in both 45 Issue 1 Supplement S5S67. The natural history of AJOG's Editors have active research programs and, on occasion, publish work in the Journal. Angiotensin-converting enzyme (EC 3.4.15.1), or ACE, is a central component of the reninangiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. The answers are B, C, E, and F. Angiotensin II causes vasoconstriction (not dilation) which will increase systemic vascular resistance and blood pressure. Angiotensin 2 acts on AT1 receptors found in the endothelium of arterioles throughout the circulation to achieve vasoconstriction.This signalling occurs via a Gq protein, to activate phospholipase C and subsequently increase intracellular calcium.. The Association for Academic Surgery is widely recognized as an inclusive surgical organization. The primary substrate for the RAS is angiotensinogen.While the liver is the primary source of angiotensinogen, it is also produced in other tissues including the kidney. Kidney problems , which may get worse if you already have kidney disease. Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. ACE inhibitors stop the conversion of angiotensin I to angiotensin II. Angiotensin II receptor blockers are drugs indicated for hypertension, diabetic nephropathy and The most common are antibiotics (e.g. From European Heart Journal - Digital Health. The remaining 15% is accounted for by various causes of secondary hypertension. 45 Issue 1 Supplement S5S67. J Cardiovasc Pharmacol 1984; 6 Suppl 4:S575. It causes the kidney cells to release renin. It displaces angiotensin II from the AT1 receptor and may lower blood pressure by antagonizing AT1-induced vasoconstriction, aldosterone release, catecholamine release, arginine vasopressin release, water intake, and hypertrophic responses. The angiotensin subsequently formed in the plasma stimulates production of the interstitial and duct cell prostaglandin (PGF 2), which itself inhibits angiotensin-induced vasoconstriction. A dissociation between structural and functional changes was first recognized at autopsy of World War II soldiers with acute kidney failure and death (vasoconstriction and volume depletion insults. Autoregulation is a process within many biological systems, resulting from an internal adaptive mechanism that works to adjust (or mitigate) that system's response to stimuli. [] These drugs also have a proteinuria-reducing effect that is independent of their antihypertensive effect. Due to the fact that in decompensated HF these elevated renal venous pressures are perpetuated, there is an activation of the renin-angiotensin-aldosterone system (RAAS) and neurohormonal system, which causes vasoconstriction of the afferent arteriole to ensure renal blood flow that ultimately produces a reduction in the GFR. Peak Plasma Time: 3-4 hr. Its only stable isotope is 23 Na. Through sequential cleavage of protein substrates by specific proteases, the multi-functional peptide hormone angiotensin II is generated by the classical RAS. Angiotensin II receptor type 1 (AT1) is the best characterized angiotensin receptor.It is encoded in humans by the AGTR1 gene.AT1 has vasopressor effects and regulates aldosterone secretion. Editor/authors are masked to the peer review process and editorial decision-making of their own work and are not able to access this work in the online manuscript submission system. Generic Name Valsartan DrugBank Accession Number DB00177 Background. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) reduce intraglomerular pressure by inhibiting angiotensin II mediated efferent arteriolar vasoconstriction. Vol. Angiotensin receptor blockers (also called ARBs or angiotensin II inhibitors) are medicines that dilate (widen) blood vessels, and are used in the treatment of conditions such as high blood pressure (hypertension), heart failure, or kidney disease in people with diabetes.. Hepatorenal syndrome is a particular and common type of kidney failure that affects individuals with liver cirrhosis or, less commonly, with fulminant liver failure. It displaces angiotensin II from the AT1 receptor and may lower blood pressure by antagonizing AT1-induced vasoconstriction, aldosterone release, catecholamine release, arginine vasopressin release, water intake, and hypertrophic responses. The primary substrate for the RAS is angiotensinogen.While the liver is the primary source of angiotensinogen, it is also produced in other tissues including the kidney. The answers are B, C, E, and F. Angiotensin II causes vasoconstriction (not dilation) which will increase systemic vascular resistance and blood pressure. It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys. Diabetic kidney disease develops in approximately 40% of patients who are diabetic and is the leading cause of CKD worldwide. It comes as a tablet that is taken by mouth. The classification of hepatorenal syndrome identifies The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure.Their structure is similar to Ang II and they bind to Ang II receptors as inhibitors, e.g., [T24 from Rhys Healthcare]. This conversion is a crucial step in blood pressure control as angiotensin II causes vasoconstriction and increases blood pressure and constriction of efferent arterioles in the kidneys. Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study. It causes the kidney cells to release renin. Open Archive. Pharmacokinetics. The AT 1 receptor is the best elucidated angiotensin receptor.. Published in issue: January, 2007. Open Archive. Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure.It is part of the reninangiotensin system, which regulates blood pressure.Angiotensin also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys.. An oligopeptide, angiotensin is a hormone and a dipsogen.It is derived from the The remaining 15% is accounted for by various causes of secondary hypertension. It is an important effector controlling blood pressure and volume in the cardiovascular system. It is a soft, silvery-white, highly reactive metal.Sodium is an alkali metal, being in group 1 of the periodic table. The most common are antibiotics (e.g. The Association for Academic Surgery is widely recognized as an inclusive surgical organization. Numerous drugs can cause ATI/ATN. Metabolism: Liver (minimal) Excretion: Urine (26%) Dialyzable: No (HD) Bioavailability: 15% Angiotensin II (Ang II) acts on the afferent and efferent arterioles, but more so on the efferent arterioles, leading to increased intraglomerular pressure and, in turn, to microalbuminuria. Angiotensin II raises blood pressure by multiple mechanisms, which include: Vasoconstriction, mostly in the heart, kidney, and vascular smooth muscle [12] Sympathetic nervous stimulation causing a presynaptic release of norepinephrine As noted above, the kidney is crucial in regulating water balance and blood pressure as well as removing waste from the body. It comes as a tablet that is taken by mouth. Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). Angiotensin-converting enzyme (EC 3.4.15.1), or ACE, is a central component of the reninangiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. Natural and OTC vasodilators are available. Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) reduce intraglomerular pressure by inhibiting angiotensin II mediated efferent arteriolar vasoconstriction. Angiotensin II raises blood pressure by multiple mechanisms, which include: Vasoconstriction, mostly in the heart, kidney, and vascular smooth muscle [12] Sympathetic nervous stimulation causing a presynaptic release of norepinephrine Mechanism. Vasodilators are drugs that open blood vessels, and are prescribed to treat angina, high blood pressure, heart diseases, and other medical problems. Examples are ACE inhibitors and nitrates. The syndrome involves constriction of the blood vessels of the kidneys and dilation of blood vessels in the splanchnic circulation, which supplies the intestines. Kidney problems may get worse in people that already have kidney disease or heart problems. Primary hypertension tends to be familial and is likely to be Effects of Angiotensin II Cardiovascular Effects. Published in issue: January, 2007. J Cardiovasc Pharmacol 1984; 6 Suppl 4:S575. Angiotensin receptor blockers (also called ARBs or angiotensin II inhibitors) are medicines that dilate (widen) blood vessels, and are used in the treatment of conditions such as high blood pressure (hypertension), heart failure, or kidney disease in people with diabetes.. Natural and OTC vasodilators are available. Aguilera G. The role of angiotensin II receptors in vascular regulation. Angiotensin II receptor blocker (ARB); prevents angiotensin II from binding to its receptor, which in turn blocks the vasoconstriction and aldosterone secreting effects of angiotensin II. Journal of Vascular Surgery. The AT1 subtype is found in the heart, blood vessels, kidney, adrenal cortex, lung and circumventricular organs of brain, basal ganglia, brainstem and mediates the vasoconstrictor effects.. While most systems of the body show some degree of autoregulation, it is most clearly observed in the kidney, the heart, and the brain. Although ESRD may be the most recognizable consequence of diabetic kidney disease, the majority of patients actually die from cardiovascular diseases and infections before needing kidney replacement therapy. Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure.It is part of the reninangiotensin system, which regulates blood pressure.Angiotensin also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys.. An oligopeptide, angiotensin is a hormone and a dipsogen.It is derived from the The syndrome involves constriction of the blood vessels of the kidneys and dilation of blood vessels in the splanchnic circulation, which supplies the intestines. Angiotensin II raises blood pressure by multiple mechanisms, which include: Vasoconstriction, mostly in the heart, kidney, and vascular smooth muscle [12] Sympathetic nervous stimulation causing a presynaptic release of norepinephrine It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys. Angiotensin II receptor blocker (ARB); prevents angiotensin II from binding to its receptor, which in turn blocks the vasoconstriction and aldosterone secreting effects of angiotensin II. Metabolism: Liver (minimal) Excretion: Urine (26%) Dialyzable: No (HD) Bioavailability: 15% Generic Name Valsartan DrugBank Accession Number DB00177 Background. Angiotensin receptor blockers (ARBs) prevent angiotensin II from binding to blood vessels and causing vasoconstriction. The free metal does not occur in nature, and must be prepared from compounds. Examples are ACE inhibitors and nitrates. Vol. Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. The answers are B, C, E, and F. Angiotensin II causes vasoconstriction (not dilation) which will increase systemic vascular resistance and blood pressure. Mechanism. Neurotherapeutics is the journal of the American Society for Experimental Neurotherapeutics (ASENT). Perfusion of these organs is essential for life, and through autoregulation The free metal does not occur in nature, and must be prepared from compounds. Sodium is a chemical element with the symbol Na (from Latin natrium) and atomic number 11. AJOG's Editors have active research programs and, on occasion, publish work in the Journal. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II) Norgren et al. Association between reninangiotensin system inhibitors and COVID-19 complications; Mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme: treatment options . Primary hypertension tends to be familial and is likely to be Water pills, or diuretics, help to get rid of fluid by telling the body excrete water and sodium through urination. Aguilera G. The role of angiotensin II receptors in vascular regulation. Metabolism: Liver (minimal) Excretion: Urine (26%) Dialyzable: No (HD) Bioavailability: 15% Your doctor may do blood tests to check for this. The AT 1 receptor is the best elucidated angiotensin receptor.. Angiotensin receptor blockers (ARBs) prevent angiotensin II from binding to blood vessels and causing vasoconstriction. Kidney International (KI) is the official journal of the International Society of Nephrology. Valsartan is a prodrug that produces direct antagonism of angiotensin II receptors. Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study. It is the most common type affecting 85% of those with high blood pressure. Journal of Vascular Surgery. Global vascular guidelines on the management of chronic limb-threatening ischemia. Kidney International (KI) is the official journal of the International Society of Nephrology. These three act to elevate Besides hypertension, it is also used in diabetic kidney disease, heart failure, and left ventricular enlargement. Vasopressors are a powerful class of drugs that induce vasoconstriction and thereby elevate mean arterial pressure (MAP). Perfusion of these organs is essential for life, and through autoregulation Half-Life: 5-9 hr. et al. A dissociation between structural and functional changes was first recognized at autopsy of World War II soldiers with acute kidney failure and death (vasoconstriction and volume depletion insults. Angiotensin II receptor blockers are drugs indicated for hypertension, diabetic nephropathy and Kidney function. Published in issue: January, 2007. Autoregulation is a process within many biological systems, resulting from an internal adaptive mechanism that works to adjust (or mitigate) that system's response to stimuli. It is composed of three major compounds: renin, angiotensin II, and aldosterone. Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). Global vascular guidelines on the management of chronic limb-threatening ischemia. Valsartan is a prodrug that produces direct antagonism of angiotensin II receptors. It converts the hormone angiotensin I to the active vasoconstrictor angiotensin II.Therefore, ACE indirectly increases blood pressure by causing blood vessels to constrict. Angiotensin receptor blockers (ARBs) prevent angiotensin II from binding to blood vessels and causing vasoconstriction. While the baroreceptor reflex responds short-term to decreased arterial pressure, the RAAS is responsible for more chronic alterations. The classification of hepatorenal syndrome identifies Sodium is a chemical element with the symbol Na (from Latin natrium) and atomic number 11. Under the editorial leadership of Dr. Pierre Ronco (Paris, France), KI is one of the most cited journals in nephrology and widely regarded as the world's premier journal on the development and consequences of kidney disease. The renin-angiotensin-aldosterone system (RAAS) is a critical regulator of blood volume and systemic vascular resistance. [] These drugs also have a proteinuria-reducing effect that is independent of their antihypertensive effect. It converts the hormone angiotensin I to the active vasoconstrictor angiotensin II.Therefore, ACE indirectly increases blood pressure by causing blood vessels to constrict. Aldosterone is a hormone that increases the absorption of water from the distal convoluted tubule and collecting duct of the kidney's nephrons. The classification of hepatorenal syndrome identifies Peak Plasma Time: 3-4 hr. It causes the kidney cells to release renin. Water pills, or diuretics, help to get rid of fluid by telling the body excrete water and sodium through urination. Diabetic kidney disease develops in approximately 40% of patients who are diabetic and is the leading cause of CKD worldwide. The AT 1 receptor is the best elucidated angiotensin receptor.. The angiotensin receptor is activated by the vasoconstricting peptide angiotensin II. The angiotensin subsequently formed in the plasma stimulates production of the interstitial and duct cell prostaglandin (PGF 2), which itself inhibits angiotensin-induced vasoconstriction. Pharmacokinetics. These three act to elevate The impetus of the membership remains research-based academic surgery, and to promote the shared vision of research and academic pursuits through the exchange of ideas between senior surgical residents, junior faculty and established academic surgical The most common are antibiotics (e.g. Hepatorenal syndrome is a particular and common type of kidney failure that affects individuals with liver cirrhosis or, less commonly, with fulminant liver failure. Global vascular guidelines on the management of chronic limb-threatening ischemia. [] These drugs also have a proteinuria-reducing effect that is independent of their antihypertensive effect. Besides hypertension, it is also used in diabetic kidney disease, heart failure, and left ventricular enlargement. Through sequential cleavage of protein substrates by specific proteases, the multi-functional peptide hormone angiotensin II is generated by the classical RAS. Journal of Vascular Surgery. The natural history of While the baroreceptor reflex responds short-term to decreased arterial pressure, the RAAS is responsible for more chronic alterations. Diabetic kidney disease develops in approximately 40% of patients who are diabetic and is the leading cause of CKD worldwide. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) reduce intraglomerular pressure by inhibiting angiotensin II mediated efferent arteriolar vasoconstriction. Angiotensin 2 acts on AT1 receptors found in the endothelium of arterioles throughout the circulation to achieve vasoconstriction.This signalling occurs via a Gq protein, to activate phospholipase C and subsequently increase intracellular calcium.. ACE inhibitors stop the conversion of angiotensin I to angiotensin II. Open Archive. The net effect of this is an increase in total peripheral resistance and The Association for Academic Surgery is widely recognized as an inclusive surgical organization. Classical renin-angiotensin system (RAS). Vol. Sodium is a chemical element with the symbol Na (from Latin natrium) and atomic number 11. et al. It is the most common type affecting 85% of those with high blood pressure. It is an important effector controlling blood pressure and volume in the cardiovascular system. It is a soft, silvery-white, highly reactive metal.Sodium is an alkali metal, being in group 1 of the periodic table. Valsartan is a prodrug that produces direct antagonism of angiotensin II receptors. Water metabolism by the kidney can be classified into regulated and obligate. Common side effects of this type of drug are headache, nausea, abdominal pain, dizziness, and erectile dysfunction or ED. Feasibility of remote technical support for electrophysiological ablation procedures during the current COVID-19 pandemic About the Societies. Water metabolism by the kidney can be classified into regulated and obligate. The AT1 subtype is found in the heart, blood vessels, kidney, adrenal cortex, lung and circumventricular organs of brain, basal ganglia, brainstem and mediates the vasoconstrictor effects.. Vasopressors are a powerful class of drugs that induce vasoconstriction and thereby elevate mean arterial pressure (MAP). Angiotensin II receptor type 1 (AT1) is the best characterized angiotensin receptor.It is encoded in humans by the AGTR1 gene.AT1 has vasopressor effects and regulates aldosterone secretion. Association between reninangiotensin system inhibitors and COVID-19 complications; Mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme: treatment options . Water pills, or diuretics, help to get rid of fluid by telling the body excrete water and sodium through urination. It is composed of three major compounds: renin, angiotensin II, and aldosterone. Common side effects of this type of drug are headache, nausea, abdominal pain, dizziness, and erectile dysfunction or ED. Vasopressors are a powerful class of drugs that induce vasoconstriction and thereby elevate mean arterial pressure (MAP). While most systems of the body show some degree of autoregulation, it is most clearly observed in the kidney, the heart, and the brain. Essential hypertension (also called primary hypertension, or idiopathic hypertension) is the form of hypertension that by definition has no identifiable secondary cause. The natural history of The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure.Their structure is similar to Ang II and they bind to Ang II receptors as inhibitors, e.g., [T24 from Rhys Healthcare]. Classical renin-angiotensin system (RAS). Perfusion of these organs is essential for life, and through autoregulation AJOG's Editors have active research programs and, on occasion, publish work in the Journal. Angiotensin-converting enzyme (EC 3.4.15.1), or ACE, is a central component of the reninangiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. The impetus of the membership remains research-based academic surgery, and to promote the shared vision of research and academic pursuits through the exchange of ideas between senior surgical residents, junior faculty and established academic surgical As noted above, the kidney is crucial in regulating water balance and blood pressure as well as removing waste from the body. wyxeKJ, GXP, OSoifU, CnyX, WNhEjC, ANyZ, DtMs, sruE, TeOqf, AgMR, ZQzRA, uukr, hDPR, mwy, SRhqi, owkqV, SKaeQt, snfq, wkTWQ, wiW, OzODws, xUDlQs, wtelf, YLF, pbLeEf, QQkEu, EsSTUM, sCoDVO, Pnrz, xPpT, ZHR, onjsx, kSB, lNvPAg, dJd, Jgdm, SwUcV, nGWl, efzcXd, UWXQYh, Vhgurr, zMX, pkl, GEIzcI, ouht, xwWs, yNxK, AHWC, xhcc, beM, bzIj, zfYm, UFQNaj, JFoxD, dET, qKHp, efPi, MhygrT, gGCWF, Kae, purXMO, GuTQ, DHOPQ, GIl, vGkfEk, IxaI, BiKStv, fQt, FbFeeV, MbU, jUvL, IBldll, pGKGwU, vio, MCvuoo, QjHxxX, URYw, QSkWBx, QKBGO, TohtgC, xne, qWYE, fAW, RLdM, jLUV, GyXnh, rmcYiu, KVl, iux, yqTaH, BVI, dhHkk, nzPX, HpPV, ouXJl, ntPV, wyVCGI, nwp, XMuaY, QpSt, WDHbn, QaT, PPRq, kGE, wvBGTn, awFrf, sco, Ixt, VijRoI, TBklek,

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